Dr. Alfredo Trevino, one of several influence for Hannibal Lecter
Fact is stranger than fiction, for sure, but I think fact is often a lot scarier than fiction, and this post is bound to be proof of that. As long as there has been writing, there have been characters inspired by real-life killers. The benefit of fiction is that you can stop when you like; this is what every single creator did in films and television examples you will see below.
1. Silence of the Lambs
Buffalo Bill was a transgender serial killer and couturier in the movie Silence of the Lambs who's famous for the line "it puts the lotion on its skin or else it gets the hose again". This was the serial killer that Clarice Starling was hunting when she first spoke with Dr. Hannibal Lecter. Throughout the film, Hannibal gave Clarice little bits and pieces of information in order to help in his capture. At this point the bodies of 5 women have been discovered throughout a rural area who were skinned.
Meanwhile the killer, Jame Gumb, has taken a victim who he intends to kill after she has been starved for a few days. The FBI eventually discover the location of Jame Gumb's house, where he is shot and killed by Clarice Starling after a brief skuffle.
"Buffalo Bill", as he was known in the press, had abducted, skinned and killed several other women, all in the hopes of collecting enough skin to make a "person suit" out of human skin.